مهندسی ساخت و تولید ایران

مهندسی ساخت و تولید ایران

طراحی و ساخت سیستم میکروفلوئیدیک مبتنی بر کریستال مایع کایرال و فناوری CNC برای تشخیص سدیم کلراید

نوع مقاله : مقاله پژوهشی

نویسندگان
1 دانشکده مهندسی مکانیک، دانشگاه علم و صنعت ایران، تهران، ایران
2 گروه مهندسی مکانیک، دانشگاه ملی مهارت، تهران، ایران
10.22034/ijme.2025.537359.2113
چکیده
این مطالعه به بررسی کاربرد کریستال‌های مایع کایرال (CLC) در سیستم‌های میکروفلوئیدیک برای تشخیص دقیق غلظت‌های سدیم کلراید می‌پردازد. ابتدا، یک سیستم نوری مبتنی بر کریستال مایع 5CB طراحی شد که شامل منبع نور، پلاریزر، میکروسکوپ نوری و تجهیزات ثبت تغییرات رنگی بود. محلول‌های سدیم کلراید با غلظت‌های مختلف به‌صورت دستی با میکروپیپت به کریستال مایع تزریق و تغییرات رنگی ثبت گردید. این روش، اگرچه در شناسایی تغییرات رنگی مؤثر بود، اما به دلیل تزریق دستی و نیاز به تجهیزات نوری اضافی، محدودیت‌هایی در قابلیت حمل و کاربرد عملی داشت. برای رفع این مشکلات، کریستال مایع کایرال (CLC) با ترکیب 5CB و ناخالصی کایرال BDH1305 جایگزین 5CB شد تا حساسیت به تغییرات غلظت افزایش یافته و نیاز به پلاریزرهای خارجی حذف گردد. چیپ‌های میکروفلوئیدیک با استفاده از دستگاه فرز رومیزی CNC سفارشی ساخته شدند که میکروکانال‌هایی با دقت میکرونی (عرض ۲۰۰ میکرومتر و عمق ۳۰۰ میکرومتر) روی ورق‌های PMMA حکاکی نمود. این دستگاه با طراحی پیشرفته و کنترل دقیق، جریان یکنواخت محلول‌ها را به مخزن CLC تضمین کرد. تصاویر ثبت‌شده با نرم‌افزار ImageJ پردازش و مقادیر RGB برای تحلیل تغییرات رنگی استخراج گردید. نتایج نشان داد که سیستم میکروفلوئیدیک مبتنی بر کریستال مایع کایرال، به‌لطف دقت تولیدی دستگاه CNC، تغییرات رنگی یکنواخت و دقیقی را ثبت کرده و غلظت‌های سدیم کلراید را با دقت بالا اندازه‌گیری می‌نماید. این سیستم نوآورانه، با ترکیب فناوری CNC و حسگری CLC، ابزاری کارآمد برای اندازه‌گیری غلظت در پزشکی، صنایع غذایی و علوم زیست‌محیطی ارائه می‌دهد و پتانسیل بالایی برای توسعه آینده دارد.
کلیدواژه‌ها

عنوان مقاله English

Design and fabrication of a microfluidic system based on chiral liquid crystal and CNC technology for sodium chloride detection

نویسندگان English

Seyed Mostafa Hosseinalipour 1
Milad Esfandiar 2
Hossein Rahimi Asiabaraki 2
Ali BashiriNezhad 1
1 Mechanical Engineering Department, Iran University of Science & Technology, Tehran, Iran
2 Department of Mechanical Engineering, Technical and Vocational University (TVU), Tehran, Iran
چکیده English

This study investigates the application of chiral liquid crystals (CLCs) in microfluidic systems for precise detection of sodium chloride concentrations. Initially, an optical system based on 5CB liquid crystal was designed, consisting of a light source, polarizer, optical microscope, and color change recording equipment. Sodium chloride solutions with different concentrations were manually injected into the liquid crystal using a micropipette, and the color changes were recorded. Although this method was effective in detecting color variations, it faced limitations in portability and practical application due to manual injection and the need for additional optical components. To address these challenges, chiral liquid crystal (CLC) fabricated by mixing 5CB with BDH1305 chiral dopant replaced pure 5CB to enhance sensitivity to concentration changes and eliminate the need for external polarizers. Microfluidic chips were fabricated using a custom-built desktop CNC milling machine, which engraved microchannels with micron precision (200 μm width and 300 μm depth) on PMMA sheets. This device, with its advanced design and precise control, ensured uniform flow of solutions to the CLC reservoir. Recorded images were processed using ImageJ software, and RGB values were extracted for color change analysis. Results demonstrated that the microfluidic-CLC system, owing to the fabrication precision of the CNC device, recorded uniform and accurate color changes and measured sodium chloride concentrations with high accuracy. This innovative system, combining CNC technology and CLC sensing, provides an efficient tool for concentration measurement in medicine, food industry, and environmental sciences, with high potential for future development.

کلیدواژه‌ها English

Chiral Liquid Crystal
Microfluidic System
CNC Machine
Concentration Detection
Color Changes
RGB Analysis
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